Glass-like, non-adsorbing, ultra-low-leaching infusion bag for premixed drugs
MediTect™ IV bag
| Primary containers designed to prevent all interaction with drug contents | ZACROS creates differentiated, novel containers that enable historically unstable drugs to be packaged in their liquid form and immediately administered to a patient.
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Our MediTect™ brand
MediTect™ packaging is dedicated to maintain sensitive liquid pharmaceuticals in their original state from formulation to administration
Functionality
Containing cyclic polyolefins (also known as COC or COP), MediTect™ products combine an unparalleled level of chemical compatibility and sorption resistance with an ultra-low extractables profile.
These properties provide product integrity and help maximize the shelf life for the most demanding applications.
Ultra-low interaction
Ultra-low sorption and leachables
Safe materials
Non-PVC and DEHP free
Alternative to rigid containers
Highly flexible bag which maintains glass-like performance
Multiple sterilization methods
Gamma, e-beam, and even terminal sterilization
Bag options and properties
Thanks to our proprietary technology, we managed to transform cyclic polyolefins (commonly known as COC or COP) into a flexible film, referred as "NI film", and combine it with other polyolefin films.
Depending on requirements, this NI film can be either laminated between 2 polyolefin films (Inter layer), or directly in contact with the drug product (Inner layer).
Below are information about our standard bag options.
Customization is available upon request, to suit the needs of your project (drug content, sterilization method, shelf-life, etc.).
Japan Lineup
Our bags have been commercialized in Japan for over 15 years.
Their configuration is adapted to local filling machines, which includes rigid ports and closures that require ultrasonic welding.
Horizontally scroll for viewing
| MediTect ASP-J | MediTect TS-J | |
| Materials | PE base, NI inter layer | PP base, NI inner layer |
| Fill volumes | 50 mL - 100 mL | 50 mL - 100 mL |
| On-bag printing | Yes | Yes |
| WVTR (g/m²/day) | 1.5 | 1.1 |
| Recommended Sterilization Method | Radiation pre-sterilization | Autoclave steam terminal sterilization |
The NI layer is composed of cyclic polyolefins (also known as COC or COP)
Based on ZACROS internal study.
Water Vapor Transmission Rate (WVTR) test conditions: 40℃, 100% RH.
Global Lineup (under development)
ZACROS is developing bags that fit with global standards in terms of filling machines and spike ports,
with both single and double port configurations.
Samples are readily available for testing.
Please contact us for more details.
Horizontally scroll for viewing
| MediTect ASP | MediTect TS | |
| Materials | PE base, NI inner layer | PP base, NI inner layer |
| Fill volumes | 100 mL - 250 mL - 500 mL | 100 mL - 250 mL - 500 mL |
| OTR (cc/m²/day/atm) | 7.6x10² | 5.7x10² |
| WVTR (g/m²/day) | 1.7 | 1.4 |
| Recommended Sterilization Method | Radiation pre-sterilization | Autoclave steam terminal sterilization |
The NI layer is composed of cyclic polyolefins (also known as COC or COP)
Based on ZACROS internal study.
Oxygen Transmission Rate (OTR) test conditions: 30℃, 70% RH.
Water Vapor Transmission Rate (WVTR) test conditions: 40℃, 90% RH.
Accessory products
IV connectors
Our bags are provided with dedicated ports and closures.
This includes rubber stoppers suited for ultrasonic welding for rigid ports, or twist-off spike ports intended for standard soft ports.
ZACROS works with major suppliers in the industry to provide components adapted to our customers' requirements.
One-touch Caps
Intended for aseptically filled products, this snap-on port system is an alternative to closures that require a welder.
They offer the following benefits:
- Close and finish with the push of a finger
- No extra capital investment required
- Easy Container Closure Integrity (CCI)
- Zero particle generation, which prevents contamination of clean rooms
- Patent and design licenses acquired for Japan, the US and EU
- By design, caps cannot reseal, which acts as tampering prevention
Secondary packaging
Overwraps are an economic way to keep contents and primary packaging clean, with the possibility to add barrier properties as desired.
Our pouches come in a variety of shapes, sizes, and colors, and can be made with various materials of construction.
- Besides aluminium pouches, we can provide transparent products that offer a wide range of barrier properties, such as UV blocking, oxygen barrier, or moisture barrier.
- Printing is also available in multiple colors for improved, easy-to-identify labeling designs.
Tamper-evident film
Designed to protect IV bags from tampering and contamination, these seals are available in a wide range of colors and configurations. They can also be tailored to cutomer's requirements.
- Customized printing
- Customized dimensions
- Customized materials of construction
- Easy-peel processing
- Heat resistance and compatibility with autoclave sterilization
The ideal container for sensitive ready-to-use injectables
Unlike convential plastic containers, MediTect™ bags offer low-sorption, low-elution properties, which enable unstable pharmaceuticals to be manufactured as ready-to-administer, premixed drugs.
Safety
Premixed drugs are essentially a closed system, which mitigates risk of exposing medical workers and patients to harmful chemicals.
Error Prevention
Preparation for injectables requires a significant amount of work and accuracy, so there is a risk of human error. Premixed bags virtually eliminate this risk as a grab-and-go solution.
Speed
Reconstitution time for injectables can take an average of 5 minutes whereas preparing a premixed bag takes a fraction of that time.
